human NR1H3 Over-expression AAV

Name
AAV-h-NR1H3

Cat No
AAV-217035

Availability
4-5 weeks

This is an AAV expressing Human NR1H3.

AAV-217035

AAV-h-NR1H3

Ready-to-use AAV expressing Human NR1H3 (nuclear receptor subfamily 1 group H member 3). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

LXR-a; LXRA; RLD-1

Description (Vector)

NR1H3 belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Gene ID

10062

Gene Name (Vector)

nuclear receptor subfamily 1 group H member 3

Gene Symbol

NR1H3

HGNC ID

HGNC:7966

ORF Size (aa)

1209

ORF Size (bp)

1209 bp

RefSeq ID

NM_005693

RefSeq Synonyms

NM_005693, NM_001251935, NM_001251934, NM_001130102, NM_001130101, BC041172, BC008819,

Species

human

UniGene ID

Hs.438863

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.