mouse WEE1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Wee1.
shADV-276255
Ad-m-WEE1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Wee1 (WEE 1 homolog 1 (S. pombe)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Wee1A
Description (Vector)
Acts as a negative regulator of entry into mitosis (G2 to M transition) by protecting the nucleus from cytoplasmically activated cyclin B1-complexed CDK1 before the onset of mitosis by mediating phosphorylation of CDK1 on 'Tyr-15'. Specifically phosphorylates and inactivates cyclin B1-complexed CDK1 reaching a maximum during G2 phase and a minimum as cells enter M phase. Phosphorylation of cyclin B1-CDK1 occurs exclusively on 'Tyr-15' and phosphorylation of monomeric CDK1 does not occur. Its activity increases during S and G2 phases and decreases at M phase when it is hyperphosphorylated. A correlated decrease in protein level occurs at M/G1 phase, probably due to its degradation.
Gene ID
22390
Gene Name (Vector)
WEE 1 homolog 1 (S. pombe)
Gene Symbol
Wee1
ORF Size (aa)
1941
ORF Size (bp)
1941 bp
RefSeq ID
NM_009516
RefSeq Synonyms
NM_009516, BC006852,
Species
mouse
UniGene ID
Mm.287173
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.