mouse VPS4B shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Vps4b.
shADV-276072
Ad-m-VPS4B-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Vps4b (vacuolar protein sorting 4B). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
8030489C12Rik; Skd1
Description (Vector)
Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses).
Gene ID
20479
Gene Name (Vector)
vacuolar protein sorting 4B
Gene Symbol
Vps4b
ORF Size (aa)
1335
ORF Size (bp)
1335 bp
RefSeq ID
NM_009190
RefSeq Synonyms
NM_009190, BC003799,
Species
mouse
UniGene ID
Mm.18705
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.