mouse UCHL3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Uchl3.
shADV-275560
Ad-m-UCHL3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Uchl3 (ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Description (Vector)
Deubiquitinating enzyme (DUB) that controls levels of cellular ubiquitin through processing of ubiquitin precursors and ubiquitinated proteins. Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. Has a 10-fold preference for Arg and Lys at position P3". Deubiquitinates ENAC in apical compartments, thereby regulating apical membrane recycling. Indirectly increases the phosphorylation of IGFIR, AKT and FOXO1 and promotes insulin-signaling and insulin-induced adipogenesis. Required for stress-response retinal, skeletal muscle and germ cell maintenance. May be involved in working memory. Can hydrolyze UBB(+1), a mutated form of ubiquitin which is not effectively degraded by the proteasome and is associated with neurogenerative disorders.
Gene ID
50933
Gene Name (Vector)
ubiquitin carboxyl-terminal esterase L3 (ubiquitin thiolesterase)
Gene Symbol
Uchl3
ORF Size (aa)
693
ORF Size (bp)
693 bp
RefSeq ID
NM_016723
RefSeq Synonyms
NM_016723, BC048481,
Species
mouse
UniGene ID
Mm.275970
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.