mouse TYRO3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Tyro3.
shADV-275410
Ad-m-TYRO3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Tyro3 (TYRO3 protein tyrosine kinase 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AI323366; Brt; Dtk; Etk-2; etk2/tyro3; Rse; Sky; Tif; tk19-1; TK19-2
Description (Vector)
Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
Gene ID
22174
Gene Name (Vector)
TYRO3 protein tyrosine kinase 3
Gene Symbol
Tyro3
ORF Size (aa)
2643
ORF Size (bp)
2643 bp
RefSeq ID
NM_019392
RefSeq Synonyms
NM_019392, NM_001290800, BC082325, BC066058,
Species
mouse
UniGene ID
Mm.424496
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.