human NMI Over-expression AAV

Name 
AAV-h-NMI
Cat No 
AAV-216826
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human NMI.

AAV-216826
AAV-h-NMI

Ready-to-use AAV expressing Human NMI (N-myc and STAT interactor). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
Nmi; N-myc and STAT interactor; N-myc-interactor
Description (eCommerce)
N-Myc Interactor (NMI) was identified as a protein that interacts with N-Myc and C-Myc transcription factors as well as the STAT (Signal Transducers and Activators of Transcription) family of transcription factors. NMI has also been found to be a component of a transcription complex with BRCA1 and c-Myc; the complex functions to inhibit human telomerase reverse transcriptase (hTERT) gene transcription.
Description (Vector)
NMYC interactor (NMI) encodes a protein that interacts with NMYC and CMYC (two members of the oncogene Myc family), and other transcription factors containing a Zip, HLH, or HLH-Zip motif. The NMI protein also interacts with all STATs except STAT2 and augments STAT-mediated transcription in response to cytokines IL2 and IFN-gamma. The NMI mRNA has low expression levels in all human fetal and adult tissues tested except brain and has high expression in cancer cell line-myeloid leukemias.
Gene ID
9111
Gene Name (eCommerce)
N-myc and STAT interactor
Gene Name (Vector)
N-myc and STAT interactor
Gene Symbol
NMI
HGNC ID
HGNC:7854
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
924
ORF Size (bp)
924 bp
Protein Name (eCommerce)
N-myc-interactor
RefSeq ID
NM_004688
RefSeq Synonyms
NM_004688, BC021987, BC001268,
Research Areas
Cancer,Immunology,Interleukin Signaling,JAK-STAT Signaling,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cell_biology,immunology,signal_transduction,transcription_translation
Species
human
Target Sentence
N-Myc Interactor (NMI) was identified as a protein that interacts with N-Myc and C-Myc transcription factors as well as the STAT (Signal Transducers and Activators of Transcription) family of transcription factors. NMI has also been found to be a component of a transcription complex with BRCA1 and c-Myc; the complex functions to inhibit human telomerase reverse transcriptase (hTERT) gene transcription.
UniGene ID
Hs.54483
UniProt ID (eCommerce)
Q13287

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.