mouse TLR4 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Tlr4.
shADV-274280
Ad-m-TLR4-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Tlr4 (toll-like receptor 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Lps; Ly87; Ran/M1; Rasl2-8
Description (Vector)
Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by Ni(2+). These responses require non-conserved histidines and are, therefore, species-specific.
Gene ID
21898
Gene Name (Vector)
toll-like receptor 4
Gene Symbol
Tlr4
ORF Size (aa)
2508
ORF Size (bp)
2508 bp
RefSeq ID
NM_021297
RefSeq Synonyms
NM_021297, BC029856,
Species
mouse
UniGene ID
Mm.38049
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.