mouse SSRP1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Ssrp1.
shADV-273189
Ad-m-SSRP1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Ssrp1 (structure specific recognition protein 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
C81323; Hmg1-rs1; Hmgi-rs3; Hmgox; T160
Description (Vector)
Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II). Binds specifically to double-stranded DNA and at low levels to DNA modified by the antitumor agent cisplatin. May potentiate cisplatin-induced cell death by blocking replication and repair of modified DNA. Also acts as a transcriptional coactivator for p63/TP63.
Gene ID
20833
Gene Name (Vector)
structure specific recognition protein 1
Gene Symbol
Ssrp1
ORF Size (aa)
2136
ORF Size (bp)
2136 bp
RefSeq ID
NM_182990
RefSeq Synonyms
NM_182990, NM_001136081, BC042502,
Species
mouse
UniGene ID
Mm.219793
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.