human NFATC2 Over-expression AAV

Name 
AAV-h-NFATC2
Cat No 
AAV-216631
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human NFATC2.

AAV-216631
AAV-h-NFATC2

Ready-to-use AAV expressing Human NFATC2 (nuclear factor of activated T-cells 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
NFAT pre-existing subunit; NFAT transcription complex, preexisting component; NFAT1; NFATc2; NF-ATc2; NFATP; NF-ATp; nuclear factor of activated T-cells, cytoplasmic 2; nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2; nuclear factor of activated T-cells, preexisting component; preexisting nuclear factor of activated T-cells 2; T cell transcription factor NFAT1; T-cell transcription factor NFAT1
Description (eCommerce)
Nuclear factor of activated T cells 1(NFAT1) is a member of the NFAT family of transcription factors which includes NFAT1 (NFATp/NFATc2), NFAT2 (NFATc/NFATc1), NFAT3 (NFATc4), and NFAT4 (NFATc3/NFATx). Different members of the NFAT family are expressed in a distinct but overlapping set of cell types. NFAT1 plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. NFAT1 is a member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFAT1 and an inducible nuclear component NFAT2 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q13469].
Description (Vector)
NFATC2 is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized.
Gene ID
4773
Gene Name (eCommerce)
nuclear factor of activated T cells 2
Gene Name (Vector)
nuclear factor of activated T-cells 2
Gene Symbol
NFATC2
HGNC ID
HGNC:7776
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2778
ORF Size (bp)
2778 bp
Protein Name (eCommerce)
Nuclear factor of activated T-cells, cytoplasmic 2
RefSeq ID
NM_012340
RefSeq Synonyms
NM_173091, NM_012340, NM_001258297, NM_001258296, NM_001258295, NM_001258294, NM_001258292, NM_001136021, BC144074, BC136418,
Research Areas
Axon Guidance,B-cell Receptor Signaling,Cardiac Development,Cardiology,Cardiovascular,Cytoskeleton,DNA Damage/Repair,Fc Receptor Signaling,Host-Virus Interactions,Immunology,Innate Immunity,Neurobiology,NFAT Signaling,Signal Transduction,T-cell Receptor Signaling,Transcription Factor/Regulator,VEGF Signaling,Wnt Signaling
Research Areas (Faceted)
signal_transduction,neurobiology,immunology,cardiovascular,cell_biology,genetics,transcription_translation,signal_transduction,immunology,infectious_disease,immunology,neurobiology,signal_transduction,genetics,transcription_translation,developmental_biology
Species
human
Target Sentence
Nuclear factor of activated T cells 1(NFAT1) is a member of the NFAT family of transcription factors which includes NFAT1 (NFATp/NFATc2), NFAT2 (NFATc/NFATc1), NFAT3 (NFATc4), and NFAT4 (NFATc3/NFATx). Different members of the NFAT family are expressed in a distinct but overlapping set of cell types. NFAT1 plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2, IL-3, IL-4, TNF-alpha or GM-CSF. NFAT1 is a member of the multicomponent NFATC transcription complex that consists of at least two components, a pre-existing cytoplasmic component NFAT1 and an inducible nuclear component NFAT2 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q13469].
UniGene ID
Hs.713650
UniProt ID (eCommerce)
Q13469

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.