mouse SIRPA shRNA silencing Adenovirus

Name 
Ad-m-SIRPA-shRNA
Cat No 
shADV-272003
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Mouse SIRPA.

shADV-272003
Ad-m-SIRPA-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse SIRPA (signal-regulatory protein alpha). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
AI835480; Bit; CD172a; P84; Ptpns1; SHP-1; SHPS-1; SIRP
Description (Vector)
Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.
Gene ID
19261
Gene Name (Vector)
signal-regulatory protein alpha
Gene Symbol
SIRPA
ORF Size (aa)
1530
ORF Size (bp)
1530 bp
RefSeq ID
NM_007547
RefSeq Synonyms
NM_007547, NM_001291022, NM_001291021, NM_001291020, NM_001291019, NM_001177647, NM_001177646, BC062197,
Species
mouse
UniGene ID
Mm.1682

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.