mouse RPS6KA4 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Rps6ka4.
shADV-271099
Ad-m-RPS6KA4-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Rps6ka4 (ribosomal protein S6 kinase, polypeptide 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
1110069D02Rik; 90kDa; AI848992; mMSK2; Msk2
Description (Vector)
Serine/threonine-protein kinase that is required for the mitogen or stress-induced phosphorylation of the transcription factors CREB1 and ATF1 and for the regulation of the transcription factor RELA, and that contributes to gene activation by histone phosphorylation and functions in the regulation of inflammatory genes. Phosphorylates CREB1 and ATF1 in response to mitogenic or stress stimuli such as UV-C irradiation, epidermal growth factor (EGF) and anisomycin. Plays an essential role in the control of RELA transcriptional activity in response to TNF. Phosphorylates 'Ser-10' of histone H3 in response to mitogenics, stress stimuli and EGF, which results in the transcriptional activation of several immediate early genes, including proto-oncogenes c-fos/FOS and c-jun/JUN. May also phosphorylate 'Ser-28' of histone H3. Mediates the mitogen- and stress-induced phosphorylation of high mobility group protein 1 (HMGN1/HMG14). In lipopolysaccharide-stimulated primary macrophages, acts downstream of the Toll-like receptor TLR4 to limit the production of pro-inflammatory cytokines. Functions probably by inducing transcription of the MAP kinase phosphatase DUSP1 and the anti-inflammatory cytokine interleukin 10 (IL10), via CREB1 and ATF1 transcription factors.
Gene ID
56613
Gene Name (Vector)
ribosomal protein S6 kinase, polypeptide 4
Gene Symbol
Rps6ka4
ORF Size (aa)
2322
ORF Size (bp)
2322 bp
RefSeq ID
NM_019924
RefSeq Synonyms
NM_019924, BC012964,
Species
mouse
UniGene ID
Mm.20914
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.