mouse RGMA shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Rgma.
shADV-270467
Ad-m-RGMA-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Rgma (repulsive guidance molecule family member A). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
BC059072; C230063O06
Description (Vector)
Member of the repulsive guidance molecule (RGM) family that performs several functions in the developing and adult nervous system. Regulates cephalic neural tube closure, inhibits neurite outgrowth and cortical neuron branching, and the formation of mature synapses. Binding to its receptor NEO1/neogenin induces activation of RHOA-ROCK1/Rho-kinase signaling pathway through UNC5B-ARHGEF12/LARG-PTK2/FAK1 cascade, leading to collapse of the neuronal growth cone and neurite outgrowth inhibition. Furthermore, RGMA binding to NEO1/neogenin leads to HRAS inactivation by influencing HRAS1-PTK2/FAK1-AKT1 pathway. It also functions as a bone morphogenetic protein (BMP) coreceptor that may signal through SMAD1, SMAD5, and SMAD8.
Gene ID
244058
Gene Name (Vector)
repulsive guidance molecule family member A
Gene Symbol
Rgma
ORF Size (aa)
1365
ORF Size (bp)
1365 bp
RefSeq ID
NM_177740
RefSeq Synonyms
NM_177740, BC059072, BC023870,
Species
mouse
UniGene ID
Mm.333943
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.