mouse PSMD10 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Psmd10.
shADV-269657
Ad-m-PSMD10-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Psmd10 (proteasome (prosome, macropain) 26S subunit, non-ATPase, 10). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AW554874
Description (Vector)
Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module|Function: Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export.
Gene ID
53380
Gene Name (Vector)
proteasome (prosome, macropain) 26S subunit, non-ATPase, 10
Gene Symbol
Psmd10
ORF Size (aa)
696
ORF Size (bp)
696 bp
RefSeq ID
NM_016883
RefSeq Synonyms
NM_016883, NM_001164177, BC056196, BC026931,
Species
mouse
UniGene ID
Mm.17640
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.