human NAE1 Over-expression AAV

Name 
AAV-h-NAE1
Cat No 
AAV-216285
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human NAE1.

AAV-216285
AAV-h-NAE1

Ready-to-use AAV expressing Human NAE1 (NEDD8 activating enzyme E1 subunit 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
A-116A10.1; APPBP1; HPP1; ula-1
Description (Vector)
NAE1 binds to the beta-amyloid precursor protein. Beta-amyloid precursor protein is a cell surface protein with signal-transducing properties, and it is thought to play a role in the pathogenesis of Alzheimer's disease. In addition, the encoded protein can form a heterodimer with UBE1C and bind and activate NEDD8, a ubiquitin-like protein. This protein is required for cell cycle progression through the S/M checkpoint. Three transcript variants encoding different isoforms have been found for this gene.
Gene ID
8883
Gene Name (Vector)
NEDD8 activating enzyme E1 subunit 1
Gene Symbol
NAE1
HGNC ID
HGNC:621
ORF Size (aa)
1605
ORF Size (bp)
1605 bp
RefSeq ID
NM_003905
RefSeq Synonyms
NM_003905, NM_001286500, NM_001018160, NM_001018159, BC013301, BC000480,
Species
human
UniGene ID
Hs.460978

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.