mouse PNN shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Pnn.
shADV-268960
Ad-m-PNN-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Pnn (pinin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AU045199; D12Ertd512e
Description (Vector)
Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene; the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma.
Gene ID
18949
Gene Name (Vector)
pinin
Gene Symbol
Pnn
ORF Size (aa)
2181
ORF Size (bp)
2181 bp
RefSeq ID
NM_008891
RefSeq Synonyms
NM_008891, BC138014, BC132571,
Species
mouse
UniGene ID
Mm.22347
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.