human MYOT Over-expression AAV

Name 
AAV-h-MYOT
Cat No 
AAV-216234
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human MYOT.

AAV-216234
AAV-h-MYOT

Ready-to-use AAV expressing Human MYOT (myotilin). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
LGMD1; LGMD1A; MFM3; TTID; TTOD
Description (Vector)
MYOT encodes a cystoskeletal protein which plays a significant role in the stability of thin filaments during muscle contraction. This protein binds F-actin, crosslinks actin filaments, and prevents latrunculin A-induced filament disassembly. Mutations in this gene have been associated with limb-girdle muscular dystrophy and myofibrillar myopathies. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined.
Gene ID
9499
Gene Name (Vector)
myotilin
Gene Symbol
MYOT
HGNC ID
HGNC:12399
ORF Size (aa)
1497
ORF Size (bp)
1497 bp
RefSeq ID
NM_006790
RefSeq Synonyms
NM_006790, NM_001300911, NM_001135940, BC005376,
Species
human
UniGene ID
Hs.84665

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.