mouse OTOF shRNA silencing Adenovirus

Name
Ad-m-OTOF-shRNA

Cat No
shADV-267745

Availability
7-8 weeks

This is an Adenovirus expressing shRNA for silencing of Mouse Otof.

shADV-267745

Ad-m-OTOF-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Otof (otoferlin). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Validated

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Description (Vector)

Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. Interacts in a calcium-dependent manner to the presynaptic SNARE proteins at ribbon synapses of cochlear inner hair cells (IHCs) to trigger exocytosis of neurotransmitter. Also essential to synaptic exocytosis in immature outer hair cells (OHCs). May also play a role within the recycling of endosomes (By similarity).

Gene ID

83762

Gene Name (Vector)

otoferlin

Gene Symbol

Otof

ORF Size (aa)

5934

ORF Size (bp)

5934 bp

RefSeq ID

NM_031875

RefSeq Synonyms

NM_031875, NM_001313767, NM_001286421, NM_001100395, BC150702, BC145107,

Species

mouse

UniGene ID

Mm.244502

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.