mouse NTRK2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Ntrk2.
shADV-266156
Ad-m-NTRK2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Ntrk2 (neurotrophic tyrosine kinase, receptor, type 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
GP145-TrkB/GP95-TrkB; Tkrb; trk-B; trkB
Description (Vector)
Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity. Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2. Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation. Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia.
Gene ID
18212
Gene Name (Vector)
neurotrophic tyrosine kinase, receptor, type 2
Gene Symbol
Ntrk2
ORF Size (aa)
1431
ORF Size (bp)
1431 bp
RefSeq ID
NM_008745
RefSeq Synonyms
NM_008745, NM_001282961, NM_001025074, BC052014,
Species
mouse
UniGene ID
Mm.130054
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.