mouse NOTCH2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Notch2.
shADV-265945
Ad-m-NOTCH2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Notch2 (notch 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AI853703; N2
Description (Vector)
Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity). Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation.
Gene ID
18129
Gene Name (Vector)
notch 2
Gene Symbol
Notch2
ORF Size (aa)
7422
ORF Size (bp)
7422 bp
RefSeq ID
NM_010928
RefSeq Synonyms
NM_010928, BC172642,
Species
mouse
UniGene ID
Mm.254017
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.