mouse NMRAL1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Nmral1.
shADV-265885
Ad-m-NMRAL1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Nmral1 (NmrA-like family domain containing 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
1110025F24Rik; AI256624
Description (Vector)
Redox sensor protein. Undergoes restructuring and subcellular redistribution in response to changes in intracellular NADPH/NADP(+) levels. At low NADPH concentrations the protein is found mainly as a monomer, and binds argininosuccinate synthase (ASS1), the enzyme involved in nitric oxide synthesis. Association with ASS1 impairs its activity and reduces the production of nitric oxide, which subsecuently prevents apoptosis. Under normal NADPH concentrations, the protein is found as a dimer and hides the binding site for ASS1. The homodimer binds one molecule of NADPH. Has higher affinity for NADPH than for NADP(+). Binding to NADPH is necessary to form a stable dimer.
Gene ID
67824
Gene Name (Vector)
NmrA-like family domain containing 1
Gene Symbol
Nmral1
ORF Size (aa)
930
RefSeq ID
NM_026393
RefSeq Synonyms
NM_026393, NM_001290763, NM_001290762, NM_001290761, BC030039,
Species
mouse
UniGene ID
Mm.372705
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.