mouse NHLRC1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Nhlrc1.
shADV-265755
Ad-m-NHLRC1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Nhlrc1 (NHL repeat containing 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AI505271; B230309E09Rik; EPM2B
Description (Vector)
E3 ubiquitin-protein ligase which in complex with EPM2A/laforin and HSP70 suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system (UPS). Ubiquitinates PPP1R3C/PTG in a laforin-dependent manner, and targets it for proteasome-dependent degradation and this degradation decreases glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation.
Gene ID
105193
Gene Name (Vector)
NHL repeat containing 1
Gene Symbol
Nhlrc1
ORF Size (aa)
1206
ORF Size (bp)
1206 bp
RefSeq ID
NM_175340
RefSeq Synonyms
NM_175340, BC118952, BC118951,
Species
mouse
UniGene ID
Mm.25593
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.