mouse NF2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Nf2.
shADV-265700
Ad-m-NF2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Nf2 (neurofibromin 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
merlin
Description (Vector)
Probable regulator of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway, a signaling pathway that plays a pivotal role in tumor suppression by restricting proliferation and promoting apoptosis. Along with WWC1 can synergistically induce the phosphorylation of LATS1 and LATS2 and can probably function in the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway. May act as a membrane stabilizing protein. May inhibit PI3 kinase by binding to AGAP2 and impairing its stimulating activity. Suppresses cell proliferation and tumorigenesis by inhibiting the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex.
Gene ID
18016
Gene Name (Vector)
neurofibromin 2
Gene Symbol
Nf2
ORF Size (aa)
1062
ORF Size (bp)
1062 bp
RefSeq ID
NM_010898
RefSeq Synonyms
NM_010898, NM_001252253, NM_001252252, NM_001252251, NM_001252250, BC005442,
Species
mouse
UniGene ID
Mm.297109
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.