mouse NEFH shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Nefh.
shADV-265633
Ad-m-NEFH-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Nefh (neurofilament, heavy polypeptide). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
200 kDa neurofilament protein; mKIAA0845; neurofilament 200kDa; neurofilament heavy polypeptide; neurofilament triplet H protein; NF200; Nfh; NF-H
Description (eCommerce)
Neurofilaments are type IV intermediate filament heteropolymers composed of light (L), medium (M), and heavy (H) chains. Neurofilaments are a component of the axon cytoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. NF-H is commonly used as a biomarker of neuronal damage [taken from NCBI Entrez Gene (Gene ID: 4744)].
Description (Vector)
Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. NF-H has an important function in mature axons that is not subserved by the two smaller NF proteins.
Gene ID
380684
Gene Name (eCommerce)
neurofilament, heavy polypeptide
Gene Name (Vector)
neurofilament, heavy polypeptide
Gene Symbol
Nefh
NCBI Taxonomy ID (eCommerce)
10090.0
ORF Size (aa)
3273
ORF Size (bp)
3273 bp
Protein Name (eCommerce)
Neurofilament heavy polypeptide
RefSeq ID
NM_010904
RefSeq Synonyms
NM_010904, BC168406,
Research Areas
Amyotrophic Lateral Sclerosis (ALS),Apoptosis,Cytoskeleton,Mitochondrion,Neurobiology,Neurodegeneration,Neurodevelopment
Research Areas (Faceted)
cell_biology,developmental_biology,neurobiology
Species
mouse
Target Sentence
Neurofilaments are type IV intermediate filament heteropolymers composed of light (L), medium (M), and heavy (H) chains. Neurofilaments are a component of the axon cytoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. NF-H is commonly used as a biomarker of neuronal damage [taken from NCBI Entrez Gene (Gene ID: 4744)].
UniGene ID
Mm.298283
UniProt ID (eCommerce)
P19246
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.