mouse NEDD4L shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Nedd4l.
shADV-265629
Ad-m-NEDD4L-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Nedd4l (neural precursor cell expressed, developmentally down-regulated gene 4-like). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
1300012C07Rik; Nedd4-2; Nedd4b
Description (Vector)
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2.
Gene ID
83814
Gene Name (Vector)
neural precursor cell expressed, developmentally down-regulated gene 4-like
Gene Symbol
Nedd4l
ORF Size (aa)
2568
ORF Size (bp)
2568 bp
RefSeq ID
NM_031881
RefSeq Synonyms
NM_031881, NM_001114386, BC071210, BC039746,
Species
mouse
UniGene ID
Mm.98668
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.