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mouse NANOG shRNA silencing Adenovirus

Name 
Ad-m-NANOG-shRNA
Cat No 
shADV-265423
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Mouse Nanog.

shADV-265423
Ad-m-NANOG-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Nanog (Nanog homeobox). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
2410002E02Rik; early embryo specific expression NK family; early embryo specific expression NK-type homeobox protein; ecat4; ENK; ES cell-associated protein 4; homeobox protein NANOG; homeobox transcription factor Nanog
Description (eCommerce)
Nanog is a homeobox transcription factor involved in promoting embryonic stem (ES) cell self-renewal and the delay of lineage commitment.
Description (Vector)
Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes (By similarity). Acts as a transcriptional activator or repressor (By similarity). Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3' (By similarity). When overexpressed, promotes cells to enter into S phase and proliferation (By similarity).
Gene ID
71950
Gene Name (eCommerce)
Nanog homeobox
Gene Name (Vector)
Nanog homeobox
Gene Symbol
Nanog
NCBI Taxonomy ID (eCommerce)
10090.0
ORF Size (aa)
915
Protein Name (eCommerce)
Homeobox protein NANOG
RefSeq ID
NM_001289828
RefSeq Synonyms
NM_028016, NM_001289831, NM_001289830, NM_001289828, BC144996, BC144995, BC137873, BC132017,
Research Areas
Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,transcription_translation
Species
mouse
Target Sentence
Nanog is a homeobox transcription factor involved in promoting embryonic stem (ES) cell self-renewal and the delay of lineage commitment.
UniGene ID
Mm.6047
UniProt ID (eCommerce)
Q80Z64

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.