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mouse MCAM shRNA silencing Adenovirus

Name 
Ad-m-MCAM-shRNA
Cat No 
shADV-264355
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Mouse Mcam.

shADV-264355
Ad-m-MCAM-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Mcam (melanoma cell adhesion molecule). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
1-gicerin; AV025631; CD146; CD149; Muc18; s-endo; s-gicerin
Description (Vector)
Plays a role in cell adhesion, and in cohesion of the endothelial monolayer at intercellular junctions in vascular tissue. Its expression may allow melanoma cells to interact with cellular elements of the vascular system, thereby enhancing hematogeneous tumor spread. Could be an adhesion molecule active in neural crest cells during embryonic development. Acts as surface receptor that triggers tyrosine phosphorylation of FYN and PTK2/FAK1, and a transient increase in the intracellular calcium concentration.
Gene ID
84004
Gene Name (Vector)
melanoma cell adhesion molecule
Gene Symbol
Mcam
ORF Size (aa)
1947
ORF Size (bp)
1947 bp
RefSeq ID
NM_023061
RefSeq Synonyms
NM_023061, BC026985,
Species
mouse
UniGene ID
Mm.275003

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.