mouse MARK1 shRNA silencing Adenovirus

Name 
Ad-m-MARK1-shRNA
Cat No 
shADV-264270
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Mouse Mark1.

shADV-264270
Ad-m-MARK1-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Mark1 (MAP/microtubule affinity regulating kinase 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
AW491150; B930025N23Rik; Emk3; mKIAA1477; mPar-1c; Par-1c
Description (Vector)
Serine/threonine-protein kinase involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2, MAP4 and MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3).
Gene ID
226778
Gene Name (Vector)
MAP/microtubule affinity regulating kinase 1
Gene Symbol
Mark1
ORF Size (aa)
2388
ORF Size (bp)
2388 bp
RefSeq ID
NM_145515
RefSeq Synonyms
NM_145515, BC112400,
Species
mouse
UniGene ID
Mm.7445

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.