mouse MAGEA2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Magea2.
shADV-264094
Ad-m-MAGEA2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Magea2 (melanoma antigen, family A, 2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Mage-a2
Description (Vector)
Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes.
Gene ID
17138
Gene Name (Vector)
melanoma antigen, family A, 2
Gene Symbol
Magea2
ORF Size (aa)
963
RefSeq ID
NM_020016
RefSeq Synonyms
NM_020016, BC106842,
Species
mouse
UniGene ID
Mm.326653
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.