mouse LMNA shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Lmna.
shADV-263520
Ad-m-LMNA-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Lmna (lamin A). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Dhe
Description (Vector)
Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Play an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics|Function: Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence.
Gene ID
16905
Gene Name (Vector)
lamin A
Gene Symbol
Lmna
ORF Size (aa)
1998
ORF Size (bp)
1998 bp
RefSeq ID
NM_001002011
RefSeq Synonyms
NM_019390, NM_001111102, NM_001002011, BC094020, BC015302,
Species
mouse
UniGene ID
Mm.471227
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.