mouse KLF1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Klf1.
shADV-262857
Ad-m-KLF1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Klf1 (Kruppel-like factor 1 (erythroid)). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Eklf; Nan
Description (Vector)
Transcription regulator of erythrocyte development that probably serves as a general switch factor during erythropoiesis. Is a dual regulator of fetal-to-adult globin switching. Binds to the CACCC box in the beta-globin gene promoter and acts as a preferential activator of this gene. Furthermore, it binds to the BCL11A promoter and activates expression of BCL11A, which in turn represses the HBG1 and HBG2 genes. This dual activity ensures that, in most adults, fetal hemoglobin levels are low. Able to activate CD44 and AQP1 promoters. When sumoylated, acts as a transcriptional repressor by promoting interaction with CDH2/MI2beta and also represses megakaryocytic differentiation (By similarity).
Gene ID
16596
Gene Name (Vector)
Kruppel-like factor 1 (erythroid)
Gene Symbol
Klf1
ORF Size (aa)
1131
RefSeq ID
NM_010635
RefSeq Synonyms
NM_010635, BC114978,
Species
mouse
UniGene ID
Mm.4847
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.