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mouse IL12B shRNA silencing Adenovirus

Name 
Ad-m-IL12B-shRNA
Cat No 
shADV-262096
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Mouse IL12B.

shADV-262096
Ad-m-IL12B-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse IL12B (interleukin 12b). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
Il-12b; Il-12p40; Il12p40; p40;
Description (Vector)
Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC|Function: Associates with IL23A to form the IL-23 interleukin, an heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to an heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis.
Gene ID
16160
Gene Name (Vector)
interleukin 12b
Gene Symbol
IL12B
ORF Size (aa)
1008
ORF Size (bp)
1008 bp
RefSeq ID
NM_008352
RefSeq Synonyms
NM_008352, NM_001303244, BC103614, BC103610, BC103609, BC103608,
Species
mouse
UniGene ID
Mm.239707

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.