mouse IFIH1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Ifih1.
shADV-261885
Ad-m-IFIH1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Ifih1 (interferon induced with helicase C domain 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
9130009C22Rik; Helicard; Hlcd; MDA5; RLR-2
Description (Vector)
Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include mRNA lacking 2'-O-methylation at their 5' cap and long-dsRNA (>1 kb in length). Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes, including interferons (IFNs); IFN-alpha and IFN-beta. Responsible for detecting the Picornaviridae family members such as encephalomyocarditis virus (EMCV) and mengo encephalomyocarditis virus (ENMG). Can also detect other viruses such as dengue virus (DENV), west Nile virus (WNV), and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome, such as vaccinia virus. Plays an important role in amplifying innate immune signaling through recognition of RNA metabolites that are produced during virus infection by ribonuclease L (RNase L). May play an important role in enhancing natural killer cell function and may be involved in growth inhibition and apoptosis in several tumor cell lines.
Gene ID
71586
Gene Name (Vector)
interferon induced with helicase C domain 1
Gene Symbol
Ifih1
ORF Size (aa)
2931
ORF Size (bp)
2931 bp
RefSeq ID
NM_027835
RefSeq Synonyms
NM_027835, NM_001164477, BC080200,
Species
mouse
UniGene ID
Mm.136224
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.