mouse HIVEP3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Hivep3.
shADV-261424
Ad-m-HIVEP3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Hivep3 (human immunodeficiency virus type I enhancer binding protein 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2900056N03Rik; A130075N07; AI848000; E030045D18Rik; KBP-1; KBP1; Krc; Rc; Schnurri-3; Shn3; Zas3
Description (Vector)
Plays a role of transcription factor; binds to recognition signal sequences (Rss heptamer) for somatic recombination of immunoglobulin and T-cell receptor gene segments; Binds also to the kappa-B motif of gene such as S100A4, involved in cell progression and differentiation. Kappa-B motif is a gene regulatory element found in promoters and enhancers of genes involved in immunity, inflammation, and growth and that responds to viral antigens, mitogens, and cytokines. Involvement of HIVEP3 in cell growth is strengthened by the fact that its down-regulation promotes cell cycle progression with ultimate formation of multinucleated giant cells. Strongly inhibits TNF-alpha-induced NF-kappa-B activation; Interferes with nuclear factor NF-kappa-B by several mechanisms: as transcription factor, by competing for Kappa-B motif and by repressing transcription in the nucleus; through a non transcriptional process, by inhibiting nuclear translocation of RELA by association with TRAF2, an adapter molecule in the tumor necrosis factor signaling, which blocks the formation of IKK complex. Interaction with TRAF proteins inhibits both NF-Kappa-B-mediated and c-Jun N-terminal kinase/JNK-mediated responses that include apoptosis and proinflammatory cytokine gene expression. Positively regulates the expression of IL2 in T-cell. Essential regulator of adult bone formation.
Gene ID
16656
Gene Name (Vector)
human immunodeficiency virus type I enhancer binding protein 3
Gene Symbol
Hivep3
ORF Size (aa)
7044
ORF Size (bp)
7044 bp
RefSeq ID
NM_010657
RefSeq Synonyms
NM_010657, BC172623,
Species
mouse
UniGene ID
Mm.422538
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.