mouse FXN shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Fxn.
shADV-259724
Ad-m-FXN-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Fxn (frataxin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
FA; FARR; Frda; X25
Description (Vector)
Promotes the biosynthesis of heme and assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. May play a role in the protection against iron-catalyzed oxidative stress through its ability to catalyze the oxidation of Fe(2+) to Fe(3+); the oligomeric form but not the monomeric form has in vitro ferroxidase activity. May be able to store large amounts of iron in the form of a ferrihydrite mineral by oligomerization; however, the physiological relevance is unsure as reports are conflicting and the function has only been shown using heterologous overexpression systems. Modulates the RNA-binding activity of ACO1.
Gene ID
14297
Gene Name (Vector)
frataxin
Gene Symbol
Fxn
ORF Size (aa)
624
RefSeq ID
NM_008044
RefSeq Synonyms
NM_008044, BC132337, BC125337,
Species
mouse
UniGene ID
Mm.7319
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.