mouse EPHB2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Ephb2.
shADV-258578
Ad-m-EPHB2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Ephb2 (Eph receptor B2). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Cek5; Drt; Erk; ETECK; Hek5; Nuk; Prkm5; Qek5; Sek3; Tyro5
Description (Vector)
Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Functions in axon guidance during development. Involved in the guidance of commissural axons, that form a major interhemispheric connection between the 2 temporal lobs of the cerebral cortex. Also involved in guidance of contralateral inner ear efferent growth cones at the midline and of retinal ganglion cell axons to the optic disk. Beside axon guidance, also regulates dendritic spines development and maturation and stimulates the formation of excitatory synapses. Upon activation by EFNB1, abolishes the ARHGEF15-mediated negative regulation on excitatory synapse formation. Controls other aspects of development including angiogenesis, palate development and in inner ear development through regulation of endolymph production. Forward and reverse signaling through the EFNB2/EPHB2 complex regulate movement and adhesion of cells that tubularize the urethra and septate the cloaca. May function as a tumor suppressor.
Gene ID
13844
Gene Name (Vector)
Eph receptor B2
Gene Symbol
Ephb2
ORF Size (aa)
2958
ORF Size (bp)
2958 bp
RefSeq ID
NM_010142
RefSeq Synonyms
NM_010142, NM_001290753, BC156575, BC146315, BC043088,
Species
mouse
UniGene ID
Mm.250981
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.