mouse EPHA3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Epha3.
shADV-258566
Ad-m-EPHA3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Epha3 (Eph receptor A3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AW492086; Cek4; End3; ETK1; Hek; Hek4; Mek4; Tyro4
Description (Vector)
Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Highly promiscuous for ephrin-A ligands it binds preferentially EFNA5. Upon activation by EFNA5 regulates cell-cell adhesion, cytoskeletal organization and cell migration. Plays a role in cardiac cells migration and differentiation and regulates the formation of the atrioventricular canal and septum during development probably through activation by EFNA1. Involved in the retinotectal mapping of neurons. May also control the segregation but not the guidance of motor and sensory axons during neuromuscular circuit development.
Gene ID
13837
Gene Name (Vector)
Eph receptor A3
Gene Symbol
Epha3
ORF Size (aa)
2955
ORF Size (bp)
2955 bp
RefSeq ID
NM_010140
RefSeq Synonyms
NM_010140, BC145349, BC138643, BC138641,
Species
mouse
UniGene ID
Mm.1977
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.