mouse TDG shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Tdg.
shADV-258408
Ad-m-TDG-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Tdg (thymine DNA glycosylase). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
E130317C12Rik; JZA-3; Jza1
Description (Vector)
In the DNA of higher eukaryotes, hydrolytic deamination of 5-methylcytosine to thymine leads to the formation of G/T mismatches. This enzyme corrects G/T mispairs to G/C pairs. It is capable of hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of the DNA and a mispaired thymine. In addition to the G/T, it can remove thymine also from C/T and T/T mispairs in the order G/T >> C/T > T/T. It has no detectable activity on apyrimidinic sites and does not catalyze the removal of thymine from A/T pairs or from single-stranded DNA. It can also remove uracil and 5-bromouracil from mispairs with guanine.
Gene ID
21665
Gene Name (Vector)
thymine DNA glycosylase
Gene Symbol
Tdg
ORF Size (aa)
1266
ORF Size (bp)
1266 bp
RefSeq ID
NM_172552
RefSeq Synonyms
NM_172552, NM_011561, BC085471, BC085470, BC010315,
Species
mouse
UniGene ID
Mm.284252
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.