mouse EBI3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Ebi3.
shADV-257712
Ad-m-EBI3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Ebi3 (Epstein-Barr virus induced gene 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
EBI-3; IL-27
Description (Vector)
Cytokine with pro- and anti-inflammatory properties, that can regulate T-helper cell development, suppress T-cell proliferation, stimulate cytotoxic T-cell activity, induce isotype switching in B-cells, and that has diverse effects on innate immune cells. Among its target cells are CD4 T-helper cells which can differentiate in type 1 effector cells (TH1), type 2 effector cells (TH2) and IL17 producing helper T-cells (TH17). It drives rapid clonal expansion of naive but not memory CD4 T-cells. It also strongly synergizes with IL-12 to trigger interferon-gamma/IFN-gamma production of naive CD4 T-cells, binds to the cytokine receptor WSX-1/TCCR. Another important role of IL27 is its antitumor activity as well as its antiangiogenic activity with activation of production of antiangiogenic chemokines.
Gene ID
50498
Gene Name (Vector)
Epstein-Barr virus induced gene 3
Gene Symbol
Ebi3
ORF Size (aa)
687
ORF Size (bp)
687 bp
RefSeq ID
NM_015766
RefSeq Synonyms
NM_015766, BC008209,
Species
mouse
UniGene ID
Mm.256798
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.