mouse DICER1 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Dicer1.
shADV-257176
Ad-m-DICER1-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Dicer1 (dicer 1, ribonuclease type III). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
1110006F08Rik; D12Ertd7e; mKIAA0928
Description (Vector)
Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Also cleaves double-stranded RNA to produce short interfering RNAs (siRNAs) which target the selective destruction of complementary RNAs.
Gene ID
192119
Gene Name (Vector)
dicer 1, ribonuclease type III
Gene Symbol
Dicer1
ORF Size (aa)
5718
ORF Size (bp)
5718 bp
RefSeq ID
NM_148948
RefSeq Synonyms
NM_148948, BC172621,
Species
mouse
UniGene ID
Mm.21135
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.