mouse OPTN shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Optn.
shADV-256675
Ad-m-OPTN-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Optn (optineurin). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
4930441O07Rik; FIP2; HYPL; NRP
Description (Vector)
Plays an important role in the maintenance of the Golgi complex, in membrane trafficking, in exocytosis, through its interaction with myosin VI and Rab8. Links myosin VI to the Golgi complex and plays an important role in Golgi ribbon formation. Negatively regulates the induction of IFNB in response to RNA virus infection. Plays a neuroprotective role in the eye and optic nerve. Probably part of the TNF-alpha signaling pathway that can shift the equilibrium toward induction of cell death. May act by regulating membrane trafficking and cellular morphogenesis via a complex that contains Rab8 and hungtingtin (HD). May constitute a cellular target for adenovirus E3 14.7, an inhibitor of TNF-alpha functions, thereby affecting cell death.
Gene ID
71648
Gene Name (Vector)
optineurin
Gene Symbol
Optn
ORF Size (aa)
1755
ORF Size (bp)
1755 bp
RefSeq ID
NM_181848
RefSeq Synonyms
NM_181848, BC061185,
Species
mouse
UniGene ID
Mm.116942
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.