mouse CUL5 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Cul5.
shADV-256374
Ad-m-CUL5-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Cul5 (cullin 5). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
4921514I20Rik; 8430423K24Rik; AI852817; C030032G03Rik; C330021I08Rik; VACM-1; VACM1
Description (Vector)
Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. ECS(SOCS1) seems to direct ubiquitination of JAk2. Seems to be involved poteosomal degradation of p53/TP53 stimulated by adenovirus E1B-55 kDa protein. May form a cell surface vasopressin receptor.
Gene ID
75717
Gene Name (Vector)
cullin 5
Gene Symbol
Cul5
ORF Size (aa)
2343
ORF Size (bp)
2343 bp
RefSeq ID
NM_027807
RefSeq Synonyms
NM_027807, NM_001161618, BC075710,
Species
mouse
UniGene ID
Mm.476905
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.