mouse CSNK1G2 shRNA silencing Adenovirus

Name
Ad-m-CSNK1G2-shRNA

Cat No
shADV-256249

Availability
4-5 weeks

This is an Adenovirus expressing shRNA for silencing of Mouse Csnk1g2.

shADV-256249

Ad-m-CSNK1G2-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Csnk1g2 (casein kinase 1, gamma 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

shRNA Knockdown (%)

shRNA Validated

Yes

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names

2810429I12Rik; AI463719

Description (Vector)

Serine/threonine-protein kinase. Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity). Phosphorylates COL4A3BP/CERT, MTA1 and SMAD3. Involved in brain development and vesicular trafficking and neurotransmitter releasing from small synaptic vesicles. Regulates fast synaptic transmission mediated by glutamate. SMAD3 phosphorylation promotes its ligand-dependent ubiquitination and subsequent proteasome degradation, thus inhibiting SMAD3-mediated TGF-beta responses. Hyperphosphorylation of the serine-repeat motif of COL4A3BP/CERT leads to its inactivation by dissociation from the Golgi complex, thus down-regulating ER-to-Golgi transport of ceramide and sphingomyelin synthesis.

Gene ID

103236

Gene Name (Vector)

casein kinase 1, gamma 2

Gene Symbol

Csnk1g2

ORF Size (aa)

750

RefSeq ID

NM_134002

RefSeq Synonyms

NM_134002, NM_001159591, BC005750, BC004839,

Species

mouse

UniGene ID

Mm.29873

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.