mouse ATG3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Atg3.
shADV-253220
Ad-m-ATG3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Atg3 (autophagy related 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2610016C12Rik; APG3; Apg3l; Atg3l; PC3-96
Description (Vector)
E2-like enzyme involved in autophagy and mitochondrial homeostasis. Catalyzes the conjugation of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to phosphatidylethanolamine (PE). PE-conjugation to ATG8-like proteins is essential for autophagy. Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3.
Gene ID
67841
Gene Name (Vector)
autophagy related 3
Gene Symbol
Atg3
ORF Size (aa)
945
ORF Size (bp)
945 bp
RefSeq ID
NM_026402
RefSeq Synonyms
NM_026402, BC010809,
Species
mouse
UniGene ID
Mm.41775
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.