mouse PHACTR4 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Phactr4.
shADV-252290
Ad-m-PHACTR4-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Phactr4 (phosphatase and actin regulator 4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
3110001B12Rik; AI527228; AW495572; C330013F19Rik; mKIAA4120; N28169
Description (Vector)
Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway (By similarity).
Gene ID
100169
Gene Name (Vector)
phosphatase and actin regulator 4
Gene Symbol
Phactr4
ORF Size (aa)
2085
ORF Size (bp)
2085 bp
RefSeq ID
NM_175306
RefSeq Synonyms
NM_175306, NM_001161797, BC096033, BC075672,
Species
mouse
UniGene ID
Mm.158361
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.