mouse 5430437P03RIK shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Babam1.
shADV-251348
Ad-m-5430437P03RIK-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Babam1 (BRISC and BRCA1 A complex member 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
5430437P03Rik; Merit40
Description (Vector)
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin. In these 2 complexes, it is probably required to maintain the stability of BRE/BRCC45 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36. component.
Gene ID
68251
Gene Name (Vector)
BRISC and BRCA1 A complex member 1
Gene Symbol
Babam1
ORF Size (aa)
1002
ORF Size (bp)
1002 bp
RefSeq ID
NM_026636
RefSeq Synonyms
NM_026636, BC005692,
Species
mouse
UniGene ID
Mm.21749
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.