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human OBSCN shRNA silencing Adenovirus

Name 
Ad-h-OBSCN-shRNA
Cat No 
shADV-233511
Availability
5-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human OBSCN.

shADV-233511
Ad-h-OBSCN-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human OBSCN (obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ARHGEF30; UNC89
Description (Vector)
The obscurin gene spans more than 150 kb, contains over 80 exons and encodes a protein of approximately 720 kDa. The encoded protein contains 68 Ig domains, 2 fibronectin domains, 1 calcium/calmodulin-binding domain, 1 RhoGEF domain with an associated PH domain, and 2 serine-threonine kinase domains. This protein belongs to the family of giant sacromeric signaling proteins that includes titin and nebulin, and may have a role in the organization of myofibrils during assembly and may mediate interactions between the sarcoplasmic reticulum and myofibrils. Alternatively spliced transcript variants encoding different isoforms have been identified.
Gene ID
84033
Gene Name (Vector)
obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF
Gene Symbol
OBSCN
HGNC ID
HGNC:15719
ORF Size (aa)
501
RefSeq ID
NM_052843
RefSeq Synonyms
NM_052843, NM_001271223, NM_001098623, BC098262,
Species
human

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.