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human IL17RC shRNA silencing Adenovirus

Name 
Ad-h-IL17RC-shRNA
Cat No 
shADV-233390
Availability
5-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human IL17RC.

shADV-233390
Ad-h-IL17RC-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human IL17RC (interleukin 17 receptor C). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
90
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CANDF9; IL17-RL; IL17RL
Description (Vector)
IL17RC encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling.
Gene ID
84818
Gene Name (Vector)
interleukin 17 receptor C
Gene Symbol
IL17RC
HGNC ID
HGNC:18358
ORF Size (aa)
2163
ORF Size (bp)
2163 bp
RefSeq ID
NM_032732
RefSeq Synonyms
NM_153461, NM_153460, NM_032732, NM_001203265, NM_001203264, NM_001203263, BC006411,
Species
human

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.