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human ZFHX3 shRNA silencing Adenovirus

Name 
Ad-h-ZFHX3-shRNA
Cat No 
shADV-233062
Availability
5-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human ZFHX3.

shADV-233062
Ad-h-ZFHX3-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ZFHX3 (zinc finger homeobox 3). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
60
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
ATBF1; ATBT; ZNF927
Description (Vector)
ZFHX3 encodes a transcription factor with multiple homeodomains and zinc finger motifs, and regulates myogenic and neuronal differentiation. The encoded protein suppresses expression of the alpha-fetoprotein gene by binding to an AT-rich enhancer motif. The protein has also been shown to negatively regulate c-Myb, and transactivate the cell cycle inhibitor cyclin-dependent kinase inhibitor 1A (also known as p21CIP1). ZFHX3 is reported to function as a tumor suppressor in several cancers, and sequence variants of this gene are also associated with atrial fibrillation. Multiple transcript variants expressed from alternate promoters and encoding different isoforms have been found for this gene.
Gene ID
463
Gene Name (Vector)
zinc finger homeobox 3
Gene Symbol
ZFHX3
HGNC ID
HGNC:777
ORF Size (aa)
2661
ORF Size (bp)
2661 bp
RefSeq ID
NM_006885
RefSeq Synonyms
NM_006885, NM_001164766, BC029653,
Species
human

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.