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human ATF6B shRNA silencing Adenovirus

Name 
Ad-h-ATF6B-shRNA
Cat No 
shADV-232464
Availability
4-5 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human ATF6B.

shADV-232464
Ad-h-ATF6B-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human ATF6B (activating transcription factor 6 beta). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
shRNA Validated
Yes
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
CREB-RP; CREBL1; G13
Description (Vector)
ATF6B is a transcription factor in the unfolded protein response (UPR) pathway during ER stress. Either as a homodimer or as a heterodimer with ATF6-alpha, the encoded protein binds to the ER stress response element, interacting with nuclear transcription factor Y to activate UPR target genes. The protein is normally found in the membrane of the endoplasmic reticulum; however, under ER stress, the N-terminal cytoplasmic domain is cleaved from the rest of the protein and translocates to the nucleus. Two transcript variants encoding different isoforms have been found for this gene.
Gene ID
1388
Gene Name (Vector)
activating transcription factor 6 beta
Gene Symbol
ATF6B
HGNC ID
HGNC:2349
ORF Size (aa)
2112
ORF Size (bp)
2112 bp
RefSeq ID
NM_004381
RefSeq Synonyms
NM_004381, NM_001136153, BC077075, BC008394,
Species
human
UniGene ID
Hs.

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.