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human DLG5 shRNA silencing Adenovirus

Name 
Ad-h-DLG5-shRNA
Cat No 
shADV-231289
Availability
7-8 weeks
Categories
Adenovirus, shRNA-Silencing

This is an Adenovirus expressing shRNA for silencing of Human DLG5.

shADV-231289
Ad-h-DLG5-shRNA

Ready-to-use Adenovirus expressing shRNA for silencing of Human DLG5 (discs large MAGUK scaffold protein 5). Available with optional GFP reporter or cell-specific promoter.

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Product Details

Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Validated
No
Storage Buffer
DMEM, 2% BSA, 2.5% Glycerol
Viral Backbone
Human Adenovirus Type5 (dE1/E3)

Gene Reference Data

Alternate Names
discs large protein LP-DLG; discs large protein P-dlg; discs, large homolog 5; disks large homolog 5; large type of P-DLG; LP-DLG; PDLG; P-DLG5; placenta and prostate DLG
Description (eCommerce)
DLG5 (discs large homolog 5) is a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. DLG5 localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure [taken from NCBI GeneID:9231].
Description (Vector)
DLG5 encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined.
Gene ID
9231
Gene Name (eCommerce)
discs large MAGUK scaffold protein 5
Gene Name (Vector)
discs large MAGUK scaffold protein 5
Gene Symbol
DLG5
HGNC ID
HGNC:2904
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
5760
ORF Size (bp)
5760 bp
Protein Name (eCommerce)
Disks large homolog 5
RefSeq ID
NM_004747
RefSeq Synonyms
NM_004747, BC146794,
Research Areas
Apoptosis,Cytoskeleton,Signal Transduction
Research Areas (Faceted)
signal_transduction,cell_biology
Species
human
Target Sentence
DLG5 (discs large homolog 5) is a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. DLG5 localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure [taken from NCBI GeneID:9231].
UniGene ID
Hs.652690
UniProt ID (eCommerce)
Q8TDM6

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.